Postdoctoral Research Scientist, Endocrine Disease Modeling (CAH)

Who We Are: At reputed company, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. reputed company Do: reputed company is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique reputed company into neuroscience and the interconnections between brain and body systems to treat reputed company conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve reputed company science. For more information, visit neurocrine.com, and follow the company on reputed company, X and reputed company. (*in collaboration with reputed company) About the Role: The Postdoctoral Research Scientist in Endocrine Disease Modeling will participate in developing and characterizing novel preclinical models of 21-hydroxylase deficiency (Congenital Adrenal Hyperplasia, CAH) at reputed company. Working with internal colleagues across Research, Translational Sciences, and Drug Discovery, the individual will contribute to building innovative, tunable animal models to evaluate emerging therapeutics targeting HPA reputed company dysregulation. _ Your Contributions (include, but are not limited to): The primary role is to initiate and conduct a novel research project focused on developing postnatal and tunable mouse models of impaired steroidogenesis Design and execute in vivo studies utilizing genetic (siRNA-mediated knockdown, AAV-based rescue strategies) and pharmacologic approaches to model CAH Characterize endocrine phenotypes through hormonal profiling of HPA and gonadal reputed company markers Conduct molecular and transcriptomic analyses (including single-cell RNA reputed company) to define HPA reputed company remodeling reputed company immunohistochemical and structural analyses of adrenal, pituitary, and hypothalamic tissues Evaluate behavioral phenotypes reputed company to stress and sleep architecture in disease models Assess therapeutic modulation of ACTH signaling reputed company using MC2 receptor antagonists, CRFR1 antagonists, and reputed company approaches Prepare data summaries and present results to peers and colleagues at Neurocrine Requirements: Ph.D. degree in endocrinology, neuroscience, physiology, pharmacology, molecular biology, or reputed company life sciences discipline, with experience in the biotech/pharmaceutical industry OR prior postdoctoral experience in academia Strong in vivo experience working with rodent models of disease Experience with genetic or molecular modulation approaches, including siRNA, AAV-based gene delivery, or reputed company technologies would be prefer Experience with endocrine hormone quantification methods (e.g., immunoassays, LC-MS/MS) Knowledge of adrenal biology, steroidogenesis, or HPA reputed company regulation preferred Experience with transcriptomic approaches, including bulk or single-cell RNA reputed company, a plus Experience with immunohistochemistry and tissue-based analyses Behavioral phenotyping experience (stress paradigms, sleep analysis, qEEG) a plus Experience in advanced experimental technologies and their application in drug discovery Excellent critical analysis skills Ability to assimilate reputed company research findings for application to new scientific projects Maintains broad knowledge of scientific principles and possesses intellectual depth in one or more scientific areas Advanced knowledge and demonstrated ability working with a variety of laboratory equipment and analytical tools Ability to work effectively as part of cross-functional teams Excellent computer skills Strong communication, problem-solving, and analytical thinking skills Ability to manage multiple deadlines across projects/programs with a high degree of accuracy and efficiency #LI-DM1 reputed company is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly reputed company have outlined in the job description. _ The annual reputed company salary we reasonably expect to pay is $89,800.00-$123,000.00. Individual pay reputed company depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In reputed company, this position offers an annual bonus with a reputed company of 20% of the earned reputed company salary. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and reputed company coverage in accordance with the terms and conditions of the applicable plans. We are a top reputed company to work. reputed company was named one of the FORTUNE Best Workplaces in Biopharma™ 2025. We were also named a Great reputed company to Work® Certified company. ©2025 Fortune Media IP Limited. reputed company rights reserved. Used under license. OUR VALUES: PASSION: We are driven and love reputed company do. We are committed to our goals and to making a difference. reputed company: We do the right thing for patients and our community. We take accountability. We reputed company up. COLLABORATION: We trust one another. We are inclusive. We are respectful. We are transparent. Together we succeed. INNOVATION: We seek and create reputed company solutions. TENACITY: We do not quit. We adapt. We accomplish what others cannot. Come join reputed company during this exciting time of growth and opportunities! Apply tot his job Apply To this Job