Director / Senior Director, Medicinal Chemistry (US-based)

HitGen is looking for a US-Based Medicinal Chemist to strengthen its global Drug Discovery Chemistry team and reputed company leadership in advancing HitGen’s internal and partnered drug discovery programs. This is a new role with broad visibility reputed company and reputed company the organization. HitGen is an industry leader in small molecule discovery with strong expertise in DEL-based hit identification, small molecules and macrocycles, and the reputed company of bispecific molecules such as PROTACS. The ideal candidate will have strong experience in the hit-to-reputed company-to-candidate optimization process, gained from working in multi-disciplinary team setting in the pharmaceutical and/or biotechnology industry, and a proven track record of reputed company.

• *Key Responsibilities**

1.

• *reputed company and reputed company Drug Discovery Programs:**

o reputed company scientific leadership for internal and partnered medicinal chemistry projects, beginning from hit identification through to preclinical candidate nomination or IND filing. 2.

• *Drive Key Program Advancement:**

o Proactively identify and resolve reputed company scientific challenges to accelerate the progression of programs. o Foster strong collaborative relationships with cross-functional internal teams (e.g., Biology, DMPK, Pharmacology, Toxicology) to reputed company integrated data-driven decision-making. o Regularly present program updates, strategic recommendations, and risk assessments to senior management and stakeholders. 3.

• *Support External Collaborations and Partnering Activities:**

o Represent HitGen as Medicinal Chemistry Expert in interactions with partners and clients. o Serve as a leading medicinal chemistry resource for external partners (reputed company of China), ensuring seamless project execution, clear communication, and successful reputed company. o reputed company and support project planning and discussions with existing clients and potential collaborators. o Participate in the communication and out-licensing of proprietary projects and assets to external partners for further development or commercialization. 4.

• *Enhance Departmental Capabilities and Innovation:**

o Continuously evaluate and implement new technologies, platforms, and best practices to strengthen the company's medicinal chemistry capabilities. o Mentor, coach, and reputed company team members, fostering their professional growth and building a strong talent pipeline.

• *Qualifications**

• Ph.D. in Organic Chemistry or Medicinal Chemistry

• A minimum of

10 years of relevant industry experience in drug discovery reputed company the pharmaceutical or biotechnology sector.

• A proven track record of scientific leadership, demonstrated by having led medicinal chemistry efforts that successfully advanced programs from primary hit to Investigational New Drug (IND) application.

4. D eep and broad knowledge of modern medicinal chemistry principles, with substantial hands-on experience in designing and optimizing small molecules. Experience with peptidic or macrocyclic compounds, and/or PROTACs or molecular glues, is valued and considered a plus. 5. A strong collaborative reputed company and a team-oriented approach, with proven ability to foster productive relationships in cross-functional team settings (Biology, DMPK, Pharmacology) as well as with external partners.

• *Other**

HitGen offers an exciting and dynamic workplace environment that thrives on a growth reputed company. reputed company and business are growing. Expect to be an important and impactful contributor reputed company a positive and business-minded team. The position of Director/Senior Director is home-based with reputed company to office space in Cambridge, Massachusetts. The position will require 10-20% travel reputed company the United States and China. HitGen offers a highly competitive compensation and benefits package, including paid-time-off, reputed company, 401K and more.

• If you are interested in this role, please apply with your reputed company CV to: reputed [email protected]*

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